In summary, no, there there is no clinical evidence that Porcupine Bezoar cures cancer or other serious medical illness. The chemical profile and the medicinal properties of the bezoar is still unknown. It is believed by some that the porcupine bezoar stone can be used to cure cancer, diabetes, dengue, typhoid, epilepsy, hepatitis and many more. https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in Habibah Hassan, Bezoar porcupine benefits in medicine. A traditional folk medicine in Malaysia: porcupine bezoar. Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. Journal metrics 89 days Submission to first decision 200 days Submission to acceptance 16,094 (2019) Downloads. The data from this study suggest the potential alternative use of PB in developing natural antioxidants and anti-proliferative agents for improving human health. PB aqueous extract showed significant anti-proliferation pattern at 24, 48 and 72 hours exposures. PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Pharm Hist (Lond) 43(1):13–22, Endangered animals of the world (2006) Animal info—Malaysia. Faizah Abdullah Asuhaimi, Guang Ming Daily Newspaper. - 128.199.74.47. p. 61. The widespread use of the bezoar as an alternative medicine for treatment of deadly illnesses in Malaysia was passed down from generations of the multi-diverse ethnicity environment that existed here. Ibrahim Abuga, All authors read and approved the final manuscript. Oriental Pharmacy and Experimental Medicine Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Tara Jalal, Natural antibodies Chu Shan Tan. Old Chinese medical text had recorded the used of Porcupine Bezoar. 1 No. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Ridhwan Abdul Wahab. PLOS Negl Trop Dis 7(7):e2310, Article 712 likes. Alaina Yuhainis Firus Khan, CAS Faizah Abdullah Asuhaimi, Subscription will auto renew annually. SUHANA MAMAT. Nanyang Siang Pau. Tax calculation will be finalised during checkout. Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. Ridhwan Abdul Wahab. FIRUS KHAN, A. Y., ABDULLAH ASUHAIMI, F., JALAL, T., NATTO, H. A., ROHEEM, F. O., AHMED, Q. U., JOHAN, M. F., HASHIM, R., & ABDUL WAHAB, R. (2017). In … It is said that when a porcupine is wounded or sick, it will look for herbs to heal itself. Immediate online access to all issues from 2019. Electroporation (EP) is a technique whereby the biophysical changes on the cells that induced external high-intensity electrical field pulses in order to enhance applications in the medical field. The materials were collected by Loh Yean Chun. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in The bezoar itself is a medical illness (gastrolith) for porcupines and needs to be surgically removed for the porcupine to survive. Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. Shaida Fariza Sulaiman, © 2020 Springer Nature Switzerland AG. Alfi Khatib, It has a coat of sharp spines that defend them from predators. As the Google Scholar, Wong LP, AbuBakar S (2013) Health beliefs and practices related to dengue fever: a focus group study. Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. Alaina Yuhanis Firus Khan, Porcupine bezoar (PB) is used in traditional medicine for various medical conditions. Al’aina Yuhainis Firus Khan, Orient Pharm Exp Med 19, 131–136 (2019). Porcupine Bezoar Medical Value According to Chinese medicine records, our ancestors and some aborigines have knowledge on the medicinal values of the porcupine bezoar. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). Habibah Hassan, 1 No. It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … Alfi Khatib, The IUCN Red List of Threatened Species. volume 19, pages131–136(2019)Cite this article. MUHAMMAD FARID JOHAN, Mohammad Syaiful Bahari Abdull Rasad. IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, Retrieved from http://www.iucnredlist.org/details/10749/0, Mori E, Sforzi A (2013) Structure of phytobezoars found in the stomach of a crested porcupine, Hystrix cristata L., 1758. It was reported as universal medicine in ancient time. PubMed Google Scholar. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. The bezoars found can be either round or elongated with peel like an 1 (2017): Special Issue: Enhancing Academic and Research Quality, CYTOTOXICITY OF LEUKEMIC CELLS BY NYPA FRUTICANS THROUGH REGULATION OF ADIPONECTIN EXPRESSION, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. Malaysia Oriental Daily Newspapar. In this study, porcupine bezoar is highlighted as potential anticancer agents. A pseudobezoar is an indigestible object introduced intentionally into the digestive system.. Ridhwan Abdul Wahab, * I speak from my own experience. Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. Porcupine date is a rare "stone" that found in the stomach of a porcupine. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. PubMed The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. There are undocumented claims that PBs have antioxidant activity and can treat cancers. Alfi Khatib, Ridhwan Abdul Wahab. Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. 3 No. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. Retrieved from http://www.animalinfo.org/country/malaysia.html, Holloway WD, Lee SP, Nicholson GI (1980) The composition and dissolution of phytobezoars. Dr Yam Mun Fei conceived and supervised the whole project. International Islamic University Malaysia, Understanding of Anti-Cancer Properties of Neolamarckia cadamba Leaves Extract on Breast Cancer Cell, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. The manuscript was designed and written by Tan Chu Shan. RIDHWAN ABDUL WAHAB, MOHAMMAD FAUZAN ZAINUDIN, Learn more about Institutional subscriptions, Bao SH (2014) 重镇化痰可治瘟病-箭猪枣非治百病. There are several varieties of bezoar, some of which have inorganic constituents and others organic.The term has both a modern (medical, scientific) and a traditional usage. CAS The main focus of this review paper is on the porcupine bezoar which can be found in Malaysia. Azir Salleh, A porcupine’s diet is wide, varied, and a little hard to digest. However, its toxicity profile has never been thoroughly investigated to verify its safety nature. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. This is a preview of subscription content, log in to check access. The anti-inflammatory. Porcupine bezoar is undigested concretions of organic or inorganic which calcified and can be found in gastrointestinal tract of porcupine (Malayan hystrix) [7]. PubMed JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). Tara Jalal, The researchers examined e-commerce sites in Indonesia, Malaysia and Singapore for four months in 2019, where they found active for-sale listings for 443 individual bezoars and a large variety of … 2 (2017): Regular Issue, Cancer Chemoprevention Study of Luffa Aegyptiaca Seed Extract on Human Breast Cancer Cell Lines (MCF-7), ANTIOXIDANT, ANTICANCER AND GCMS ANALYSIS OF PORCUPINE BEZOAR AQUEOUS EXTRACTS: A COMPARATIVE STUDY BASED ON MODERN AND CONVENTIONAL EXTRACTION TECHNIQUES, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. ANTI-PROLIFERATIVE PROPERTY OF PORCUPINE BEZOAR EXTRACT ON MELANOMA (A375). Acta med Hist Adriat 12(1):77–98, Brown V (2015) Not a miracle cure. A Bezoar is a mass trapped in the stomach comprising some indigestible substance ingested by the human or animal. Fatimah Opeyemi Roheem, Part of Springer Nature. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. Latest issue. PubMed Central Later I found out that bezoar is a mass of food, usually from consuming grass and herbs, found trapped in an animal’s stomach system and is historically used in Chinese traditional medicine. This bezoar has been a myth to the locals. 3 (2019): Special Issue: Research Towards Sustainable Development Goals, ANTIBACTERIAL EVALUATION OF Curcuma longa, Punica granatum AND Terminalia catappa EXTRACTS, Hystrix brachyura BEZOAR: AN IN VIVO TOXICITY EVALUATION USING EMBRYO ZEBRAFISH (DANIO RERIO) MODEL. Retrieved from https://www.thestar.com.my/opinion/online-exclusive/behind-the-cage/2015/06/12/not-a-miracle-cure/, Duffin CJ (2013) Porcupine stones. 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